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Data from Petterson et al. [39], Pharoah and Cooke [40]; Yokoyama et al. [54]. Adapted from Wimalasundera et al. [55]. compared with 29 per 1000 in the surviving twin in different-sex pair. 2-fold risk for triplets as compared with singletons [42]. Cognitive development and social development Many studies have reported that twins have poorer cognitive abilities than singletons although one recent study from the Netherlands twin registry found no evidence of a difference in cognitive ability between singletons and twins in the same family [43].

Fertil. , 88 (2007), 283–293. 14. M. H. Bouvier-Colle, N. Varnoux, B. Salanave, P. Y. Ancel and G. Br´eart, Case-control study of risk factors for obstetric patients’ admission to intensive care units. Eur. J. Obstet. Gynecol. Reprod. , 74 (1997), 173– 177. 15. J. G. Santema, I. Koppelaar and H. C. Wallenburg, Hypertensive disorders in twin pregnancy. Eur. J. Obstet. Gynecol. Reprod. , 58 (1995), 9–13. 16. B. M. Sibai, J. Hauth, S. , Hypertensive disorders in twin versus singleton gestations. National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units.

ART twins versus spontaneous twins A more adverse outcome in IVF twins as compared with twins after spontaneous conception might be expected for reasons of maternal characteristics, similar to the situation for IVF singleton pregnancies. However, the higher rates of monozygotic twinning in spontaneous twins as compared with IVF twins (30% vs. e. IVF twins would be expected to have better outcomes than spontaneously conceived twins. However, there are conflicting findings in the casecontrol and cohort studies in the literature.

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